Shenzhen, China, 27 April 2022 – MGI, a company committed to being a world-leading life science innovator, today introduced its new commercial sequencing chemistry, HotMPS*. Developed for use on MGI’s DNBSEQ-G400 sequencer**, HotMPS* will be available in selected countries from April 2022.
HotMPS* is built on the combinatorial Probe Anchor Synthesis (cPAS) technology that underpins MGI’s proprietary DNBSEQ™ platform. It inherits DNBSEQ™’s advantages, including low error rate, low duplication rate, and minimal index hopping, while delivering breakthroughs in nucleotide and enzyme chemistry. HotMPS* provides stronger signals, reduced systematic sequence-based errors, and compatibility with commonly used library preparation methods.
Early access collaborators have successfully tested HotMPS* in applications including Whole Genome Sequencing, Whole Exome Sequencing, Transcriptome, and Metagenome Sequencing. Results demonstrated high data quality and accurate variant detection.
“A testament to our commitment to advancing life science and fostering innovation, HotMPS* is another breakthrough sequencing chemistry from MGI,” said Dr Yong Hou, General Manager of MGI Europe and Africa. “We are excited to bring our DNBSEQ-based sequencers** and this new chemistry* to market, offering customers a wider choice. MGI can accelerate sequencing projects of any scale and deliver high-quality data with the most adaptable and efficient sequencers available. Our sequencers have also been validated and certified for clinical use.”
By improving sequencing quality while lowering costs, these technologies support genomics-based health monitoring and other applications that require accurate, comprehensive, and affordable sequencing. MGI continues to advance MPS technology to empower partners, customers, and the life science industry to better understand human and other species’ genomes and cells, ultimately improving health outcomes.
Remarks:
- HotMPS sequencing reagents are available only in selected countries.
- The DNBSEQ-G400 sequencer is only available in selected countries and is configured for exclusive use with HotMPS sequencing reagents.
- Unless otherwise stated, StandardMPS and CoolMPS reagents, and their compatible sequencers, are not available in Germany, USA, Spain, UK, Hong Kong, Sweden, Belgium, Italy, Finland, Czech Republic, Switzerland, and Portugal.




