HIV-1 Drug Resistance Sequencing Products Package
Drug resistance mutations in HIV are the leading cause of antiretroviral treatment failure. Timely testing and monitoring are crucial for effective prevention and treatment. MGI’s package integrates library preparation, automated sample handling, sequencing, and analysis, covering the entire workflow from viral RNA to reporting for rapid, accurate detection.
Features include genotyping, genome assembly, mutation detection, and evolutionary tracing. Using the Stanford HIV dB, it precisely annotates drug resistance, and HIV-trace analysis visualizes molecular networks for multiple samples.
Product Components & Part Numbers
| Item No. | Product Name |
|---|---|
| 900-000609-00 | G99ARS sequencer |
| 900-000537-00 | E25RS sequencer |
| 900-000354-00 | G50 sequencer |
| 900-000206-00 | SP-100RS Automated Sample Prep System |
| 900-000147-00 | SP-960RS Automated Sample Prep System |
| 900-000152-00 | SP-960RS Automated Sample Prep System |
| 940-000722-00 | ATOPlex HIV-1 Amplification Kit (16 RXN) |
| 940-000019-00 | MGIEasy Fast PCR-FREE FS DNA Library Prep Set (16 RXN) |
| 940-000021-00 | MGIEasy Fast PCR-FREE FS DNA Library Prep Set (96 RXN) |
| 1000005278 | MGIEasy DNA Clean Beads (8 mL/tube) |
| 1000026466 | DNBSEQ OneStep DNB Make Reagent Kit (4 RXN) |
| 1000020834 | CPAS barcode primer 3 |
| 940-000410-00 | High-throughput Sequencing Set (G99 SM FCL PE150) |
| 940-001269-00 | High-throughput Sequencing Set (G99 FCL PE150) |
| 1000019862 | G50RS High-throughput Rapid Sequencing Set (FCS PE150) |
| 1000019858 | G50RS High-throughput Sequencing Set (FCL PE150) |
| 940-000567-00 | E25RS High-throughput Sequencing Set (FCL PE150) |
| 970-000281-00 | HIV-GenomePro Software |
| 900-000598-00 | HIV-GenomePro Platform |
Product Specification
| Intended use | HIV-1 genotyping and drug resistance detection |
|---|---|
| Target region | PR, RT, IN genes |
| Sample type | Viral RNA from plasma, serum and cultured strains |
| Sequencer | G99 / E25 / G50 |
| Recommended read length | PE150 |
| Recommended data volume | 1 M PE150 Reads |
| Recommended sample input | ≥100 copies per rxn |
| Recommended throughput |
16 samples/FC for DNBSEQ-E25 60 samples/FC for DNBSEQ-G99 60 samples/FC for DNBSEQ-G50 FCS 300 samples/FC for DNBSEQ-G50 FCL |
| TAT for library prep | ＜8.5 h for 16 samples |
| TAT for analysis |
＜2 h for 16 samples by DNBSEQ G99ARS ≈1h for 16 samples by HIV GenomePro platform |
System Parameters
Comprehensive Coverage
- Single panel covers the three main HIV-1 drug resistance regions: Protease (PR), Reverse Transcriptase (RT), and Integrase (IN).
Fast Turnaround Time
- Paired with the G99 sequencer, the workflow from RNA to report is completed in just 20.5 hours for 16 samples.
Detect Low-Frequency Resistance
- Deep sequencing allows detection of drug resistance at frequencies below 20%, beyond the reach of traditional Sanger sequencing.
Automation-Friendly
- Compatible with SP-100, SP-960 and HIV-GenomePro, enabling automated library prep and data analysis to save hands-on labour.
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