Stereo-seq Technology

STOmics’ Stereo-seq (SpaTial Enhanced REsolution Omics-sequencing) technology gives researchers groundbreaking spatial biology tools, delivering an unmatched field-of-view alongside subcellular resolution.

The technology enables simultaneous transcriptome analysis across tissue, cellular, subcellular, and molecular levels using fresh frozen samples. By capturing RNA in situ and applying spatial coordinate barcoding (CID), Stereo-seq generates detailed spatial gene expression profiles via DNBSEQ™—advancing our understanding of gene expression, cell morphology, and tissue microenvironments.

Unlocking the Power of Spatial Transcriptomics

Stereo-seq (SpaTial Enhanced REsolution Omics-sequencing) is a pioneering spatial omics technology that enables in-depth exploration of the whole transcriptome at true single-cell resolution. Using a range of centimetre-scale capture chips, it’s the only spatial platform capable of examining tissue samples from multiple species at nanoscale resolution.

Stereo-seq is a powerful research tool for integrating gene expression, protein expression, and other multi-omics data. It offers advanced capabilities for cell type identification, tissue microenvironment analysis, and developmental research at the cellular and organ level.

Integration of pathology and spatio-temporal omics

Our innovative staining approach made it possible to integrate the study of pathology and spatio-temporal analysis on the same tissue section.

Large field of view and high resolution

With up to decimetre-scale STOmics Chip and nanoscale DNB probes, subcellular level details can be collected from any position on an entire tissue section.

Multidimensional analysis

Ability to integrate the study of tissue staining sections with whole-genome mRNA transcriptomics and proteomics.

High compatibility

Stereo-seq is compatible with fresh frozen and FFPE samples, and has reliable performance on cells, organs and embryo sections of various species.

Stereo-seq captures mRNA within tissue samples and restores the spatial location of each cell through spatial coordination barcoding (Coordinate ID, CID). This breakthrough allows for in situ sequencing of tissues, establishing a solid foundation for understanding the intricate relationships between gene expression, cell morphology, and cellular microenvironments.

Stereo-seq has transformed research across a variety of fields, including Spatio-temporal atlas creation, species evolution, disease diagnosis, therapy, and prognosis.

With ongoing advancements in Stereo-seq and its future iterations, this technology is poised to revolutionize multiple research areas, further enhancing our understanding of human biology and the redefinition of diseases.