MGI Launches Magnetic Beads TQ01 for High-Efficiency Nucleic Acid Extraction
As COVID-19 testing has become widespread, ensuring the quality, stability, and cost control of raw materials has become critical. To address this, MGI launched its self-developed, mass-produced Magnetic Beads TQ01, a key raw material for MGI’s nucleic acid extraction reagents and the MGIEasy Stool Human DNA Extraction Kit.
Magnetic beads are essential for nucleic acid extraction. Compared with column-based methods, magnetic bead reagents are better suited to automated systems, meeting the efficiency and reliability requirements of large-scale nucleic acid testing. With rapid magnetic response, strong adsorption capacity, and automation-friendly features, Magnetic Beads TQ01 efficiently capture trace nucleic acids from diverse samples, including viral RNA/DNA and fecal genomic DNA.
Product Highlights
- Rapid magnetic response for large-scale automated extraction
- High nucleic acid binding for efficient trace DNA/RNA capture
- Extraction products compatible with downstream applications with no PCR inhibition
- Compatible with alcohol-based and non-alcohol-based extraction systems
Product Performance
Magnetic Beads TQ01 are highly uniform in particle size (CV < 5%), with minimal batch-to-batch variation, making them suitable for clinical applications. Their large surface area enhances nucleic acid adsorption, enabling efficient capture from various sample types.
Figures:
- SEM image at 1,000× magnification showing particle distribution
- SEM image at 35,000× magnification showing bead surface
Applications
1. Viral Nucleic Acid Extraction
Using MGIEasy nucleic acid extraction reagents with TQ01 beads, COVID-19 pseudovirus samples of varying concentrations can be detected reliably, achieving stable detection at 100 copies/mL. The beads demonstrate excellent viral nucleic acid capture efficiency, with Ct values showing CV < 5% over 20 replicates.
2. Fecal Genomic DNA Extraction
The MGIEasy Stool Human DNA Extraction Kit with TQ01 beads efficiently extracts genomic DNA from fecal samples (~200 mg) from healthy donors. Tests show high yield and purity both manually and on automation systems (MGISP-960 and MGISP-NE384), demonstrating effective genomic DNA extraction from complex samples.
As a core life science tool, Magnetic Beads TQ01 is MGI’s first raw material product. It supports large-scale nucleic acid testing and can be used in the preparation of extraction reagents, providing a reliable, high-performance solution for diverse laboratory applications.
