Whole-Genome Sequencing (WGS) Combination Product for Large Populations

MGI’s WGS Combination Product provides a fully integrated solution for high-depth whole genome sequencing of large population cohorts. From blood sampling to VCF output, the system automates every step—sample preparation, library construction, sequencing, and data analysis—reducing hands-on time and boosting efficiency.

With flexible hardware, optimized reagents, and advanced data processing, this solution meets the diverse needs of large-scale genomics projects, making population-scale WGS faster, more accurate, and fully scalable.

Workflow

Step 1: Sample Extraction	Step 2: Library Preparation	Step 3: Sequencing	Step 4: Data Analysis
Automated Instruments: SP-960RS Extraction Reagent: MGIEasy Magnetic Beads Blood Genomic DNA Extraction Kit (V1.0)	Automated Instruments: SP-Smart 8RS SP-960RS Library Prep Kits: MGIEasy Fast PCR-FREE FS Library Prep Set (96RXN) OneStep DNB Make Reagent Kit V2.0	Sequencer: T7RS Sequencing Reagent: T7RS High-throughput Sequencing Set (FCL PE150) V3.0	Hardware: Data Centre Appliance ZTRON-PRO-T500

Step 1: Sample Extraction

Step 2: Library Preparation

Step 3: Sequencing

Step 4: Data Analysis

Automated Instruments:

SP-960RS

Extraction Reagent:

MGIEasy Magnetic Beads Blood Genomic DNA Extraction Kit (V1.0)

Automated Instruments:

SP-Smart 8RS
SP-960RS

Library Prep Kits:

MGIEasy Fast PCR-FREE FS Library Prep Set (96RXN)
OneStep DNB Make Reagent Kit V2.0

Sequencer:

T7RS

Sequencing Reagent:

T7RS High-throughput Sequencing Set (FCL PE150) V3.0

Hardware:

Data Centre Appliance ZTRON-PRO-T500

Performance Parameters

Sample Type	Whole blood
Sample Volume	≥2 mL
Sample Input	140 μL
Nucleic Acid Type	gDNA
Concentration	≥11.5 ng/μL
Purity	OD260/OD280 1.8–2.0; OD260/OD230 ≥1.7
Integrity	No or slight degradation
Input Amount	500 ng gDNA

Product Specifications

Category	Product No.	Product Name	Quantity/NO.
Extraction Reagents	940-000633-00	MGIEasy Magnetic Beads Blood Genomic DNA Extraction Kit (V1.0)	/
Library Preps	940-000884-00	MGIEasy Fast PCR-FREE FS Library Prep Set (96RXN)	/
Library Preps	940-000036-00	OneStep DNB Make Reagent Kit V2.0	/
Sequencing Reagents	940-000268-00	T7RS High-throughput Sequencing Set (FCL PE150) V3.0	/
Sequencing Reagents	1000020834	CPAS Barcode Primer 3 Reagent Kit	/
Automation Instruments	900-000152-00	SP-960RS High-throughput Automated Sample Preparation System-Configuration 7	1
Automation Instruments	900-000503-00	Automated Sample Preparation System SP-Smart 8RS Config 4	1
Sequencers	900-000242-00	Genetic Sequencer T7RS	1
Sequencers	900-000134-00	DNB Loader MGIDL-T7RS	2
Data Processing	900-000444-00	Data Center Appliance MGI-ZTRON-PRO-T500	1

System Parameters

Fast Enzyme Digestion

Using high-quality, rapid fragmentation enzymes, library prep is completed in a single step—from digestion to end-repair—in under 1.3 hours. This ensures uniform genome coverage and superior variant detection.

Efficient and High-Quality Sequencing

T7 technology delivers accurate data with low duplication rates and minimal index hopping, producing up to 15,000 samples per year.

Seamless Automation

MGI’s proprietary platforms (SP-960RS, Smart 8RS) handle nucleic acid extraction and library prep efficiently and reliably.

Complete WGS Solution for Large Populations

Includes extraction and library prep kits, automated systems, the DNBSEQ platform, and bioinformatics software, providing a fully integrated WGS workflow for population-scale projects.