- DNBSEQ-T20×2* produces up to 50,000 WGS per year at a first sub-$100 price per genome
- DNBSEQ-T7* offers a market-leading $1.5/Gb price for sequencing consumables
- DNBSEQ-G99* delivers first-in-class PE150 runs in under 12 hours with 8–48 Gb output per run
- stLFR library prep kit enables more complete and accurate haplotype-phased genomes
HOLLYWOOD, Florida, 7 February 2023 – Complete Genomics Inc., a global life science tools leader and a subsidiary of MGI Tech Co., Ltd. (MGI), today announced a series of breakthrough products and pricing initiatives at the Advances in Genome Biology and Technology (AGBT) General Meeting.
Complete Genomics offers T Series, G Series and E Series genetic sequencers covering low-, medium-, high- and ultra-high-throughput sequencing applications.
“We have made it our mission to address the global need for faster, more cost-effective and more accurate sequencing,” said Rade Drmanac, PhD, Chief Scientific Officer of Complete Genomics. “From pathogen surveillance in the post-pandemic world to delivering on the promise of precision medicine, these solutions move the industry forward.”
DNBSEQ-T20×2: Breaking the $100 Genome Barrier
DNBSEQ-T20×2 represents the next evolution of the T Series, designed specifically for large-scale population genomics projects. Using open-type sequencing slides cut from a whole silicon wafer, a single system operates six slides simultaneously, generating up to 42 Tb per run with PE100 or up to 72 Tb per run with PE150, all within a smaller footprint than the DNBSEQ-T10×4*.
Enabled by innovative dip-immersion biochemistry, DNBSEQ-T20×2 allows consecutive robotic dipping of multiple slides into shared reagents. Immersion fluidics on uncovered silicon slides ensures highly uniform reactions across the full slide surface, delivering exceptional data quality, maximum throughput and the lowest cost per genome.
A single DNBSEQ-T20×2 system can generate up to 50,000 30× whole human genomes per year for under $100 per genome, including instrument depreciation.
The platform is equipped with two imagers and a rotational robotic arm handling six slides, supporting WGS, WGBS, WES, RNA-seq, single-cell sequencing, STOmics (large-scale spatial omics with nanoscale resolution) and pooled multi-library workflows.
“The commercialisation of DNBSEQ-T20×2 will accelerate global genomics research and medical applications,” said Dr Drmanac. “More samples can now be sequenced, or deeper, more informative data can be generated per sample at an affordable cost.”
Due to its ultra-low consumable costs achieved through high-capacity operation, DNBSEQ-T20×2 requires a minimum annual consumables commitment. The system will be commercially available in China in Q2 2023 and in the US in Q3 2023.
DNBSEQ-T7: $1.5/Gb Consumables Pricing
At AGBT, Complete Genomics also announced a new US promotional reagent price of $1.5/Gb for the DNBSEQ-T7, its flagship high-throughput sequencer.
This pricing enables access to a $150 whole genome at full DNBSEQ quality, even when sequencing as few as a dozen samples per run. Large-scale projects such as STOmics can be launched immediately using multiple DNBSEQ-T7 systems, with just three instruments capable of producing nearly 50,000 30× human WGS per year.
DNBSEQ-G99: Ultra-Fast Sequencing in Under 12 Hours
DNBSEQ-G99 is the latest addition to the G Series, offering mid- to low-throughput sequencing at unprecedented speed. Featuring a novel triangular matrix signal spot design on the flow cell, it achieves higher data density with total output ranging from 8–48 Gb per run.
With proprietary optical systems and high-precision temperature control, PE150 sequencing runs are completed in under 12 hours. Preliminary data can be delivered within 2.5 hours during PE100 or PE150 runs.
DNBSEQ-G99 played a critical role in identifying the first imported case of monkeypox in Chongqing, China. Whole-genome sequencing achieved average viral genome coverage exceeding 99.03% at depths of up to 200×. Using the bioinformatics by sequencing (BBS) mode, initial raw reads were delivered in just 9 hours.
Designed for urgent and decentralised testing scenarios, DNBSEQ-G99 significantly improves turnaround times for clinically relevant biomarkers. It is ideally suited for precision oncology, hospital-based tumour detection and public health surveillance.
Currently supported read lengths include PE50, SE100 and PE150, with longer read kits such as SE400 and PE300 planned. DNBSEQ-G99 is expected to enter the US market in Q2 2023.
stLFR Library Prep Kit
The stLFR (single-tube long fragment reads) library preparation kit is based on patented DNA co-barcoding technology, enabling synthetic long reads on DNBSEQ platforms.
This approach overcomes short-read limitations, supporting high-quality structural variant detection, haplotype phasing across more than 99% of the human genome, de novo assembly and other long-fragment applications. Combined with PCR-free WGS, stLFR enables more complete and accurate haplotype-phased genomes at an accessible cost.
About Complete Genomics
Complete Genomics Inc., a subsidiary of MGI Tech Co., Ltd., is a global life science company providing lab automation and a comprehensive sequencing portfolio spanning low to ultra-high throughput. Founded in 2005 and headquartered in San Jose, California, the company operates a local demo lab and full supply centre serving US customers.
*Products are for Research Use Only. Not for use in diagnostic procedures.
